Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer
Young Sun Kim, Hye Lim Lee, Ki Bum Lee, Joo Hun Park, Wou Young Chung, Keu Sung Lee, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang
Korean J Intern Med. 2011;26(3):304-313. Published online September 13, 2011
Background/AimsOxidative stress results in protein oxidation and is implicated in carcinogenesis. Sulfiredoxin (Srx) is responsible for the enzymatic reversal of inactivated peroxiredoxin (Prx). Nuclear factor E2-related factor 2 (Nrf2) binds to antioxidant responsive elements..
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Endoscopic Cryotherapy of Lung and Bronchial Tumors: A Systematic Review
Seon-Heui Lee, Won-Jung Choi, Sook-Whan Sung, Young-Kyoon Kim, Chi-Hong Kim, Jae-Il Zo, Kwang-Joo Park
Korean J Intern Med. 2011;26(2):137-144. Published online June 1, 2011
Background/AimsWe made a systematic review and evaluation of endoscopic cryotherapy of endobronchial tumors, investigating safety and efficacy. MethodsQualified studies regarding endoscopic cryotherapy of lung tumors were systemically evaluated ..
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Efficacy and Safety of Hepatic Arterial Infusion of Fluorouracil with Leucovorin as Salvage Treatment for Refractory Liver Metastases from Colorectal Cancer
Hyun Jung Lee, Yoon Soo Lee, Keun-Wook Lee, So Yeon Kim, Chang Jin Yoon, Dong-Yeop Shin, Yun Gyoo Lee, Se Yeon Choi, Sung-Gwon Kang, Sung-Bum Kang, Jee Hyun Kim
Korean J Intern Med. 2011;26(1):82-88. Published online March 2, 2011
Background/AimsLimited options remain for patients with metastatic colorectal cancer (CRC) after failure of standard systemic chemotherapy. Readministration of chemotherapeutic agents by hepatic arterial infusion (HAI) has the rationale of providing higher concentrations of ch..
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Anaplastic Thyroid Carcinoma Initially Presented with Abdominal Cutaneous Mass and Hyperthyroidism
Kyu-Hyoung Lim, Keun-Wook Lee, Jee Hyun Kim, So Yeon Park, Sung-Hee Choi, Jong Seok Lee
Korean J Intern Med. 2010;25(4):450-453. Published online November 27, 2010
A 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter, which she had for 1 month. About 1 week earlier, the patient had also perceived a mass in the neck area. Computed tomography revealed huge thyroid and periumbilical masses. The thyroid hor..
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Clinical Significance of Observation without Repeated Radioiodine Therapy in Differentiated Thyroid Carcinoma Patients with Positive Surveillance Whole-Body Scans and Negative Thyroglobulin
Dong-Jun Lim, Joo Hyun O, Min-Hee Kim, Ji-Hyun Kim, Hyuk-Sang Kwon, Sung-Hoon Kim, Moo-Il Kang, Bong-Yun Cha, Kwang-Woo Lee, Ho-Young Son
Korean J Intern Med. 2010;25(4):408-414. Published online November 27, 2010
Background/AimsCurrently, there is no consensus on the necessity of repeated radioiodine therapy (RAI) in patients who show iodine uptake in the thyroid bed on a diagnostic whole-body scan (DxWBS) despite undetectable thyroglobulin (Tg) levels after remnant ablation. The prese..
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The Role of Photodynamic Therapy for Hilar Cholangiocarcinoma
Young Koog Cheon
Korean J Intern Med. 2010;25(4):345-352. Published online November 27, 2010
The prognosis for hilar cholangiocarcinoma is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses results in median survival times of 4-6 months for advanced bile duct cancer. Photodyn..
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High-Dose Fentanyl Patch for Cancer Pain of a Patient with Cholangiocarcinoma
Jung Han Kim, Mi Kim, Chong Won Sung, Hyeoung Su Kim, Hyun Joo Jang, Young Chul Shin, Joo Young Jung
Korean J Intern Med. 2010;25(3):337-340. Published online August 31, 2010
We describe here a patient who obtained a good analgesic effect with high-dose fentanyl patches for controlling cancer pain. A 52-year-old man was referred to our hospital because of severe cancer pain that was 7/10 on a numeric rating scale (NRS). He had been diagnosed with locally advanced cho..
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Primary Pulmonary Biphasic Synovial Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Gene: Report of 1 Case
Jae Seok Park, Bo Ram Min, Soon Hyo Park, Kun Young Kwon, Dong-Yoon Keum, Won-Il Choi
Korean J Intern Med. 2010;25(3):331-336. Published online August 31, 2010
We experienced a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by immunohistochemistry and molecular testing of SYT-SSX2 fusion transcripts. The patient was a 61-year-old man who presented with a well-defined mass in the left upper lung field on chest radiography. Left ..
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Pemetrexed versus Gefitinib versus Erlotinib in Previously Treated Patients with Non-Small Cell Lung Cancer
Junshik Hong, Sun Young Kyung, Sang Pyo Lee, Jeong Woong Park, Sung Hwan Jung, Jae-Ik Lee, Se Hoon Park, Sun Jin Sym, Jinny Park, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee
Korean J Intern Med. 2010;25(3):294-300. Published online August 31, 2010
Background/AimsThe efficacy and safety of pemetrexed, gefitinib, and erlotinib administration in previously treated patients with non-small cell lung cancer (NSCLC) were compared. MethodsThe study patients met the following criteria: histologica..
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Two Lung Masses with Different Responses to Pemetrexed
Kwang Young Park, Jae Wook Jung, Seung Bum Nam, Ho Jin Lee, Hyo Seok Kim, Yoon Hee Choi, Jae Cheol Lee
Korean J Intern Med. 2010;25(2):213-216. Published online June 1, 2010
We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lu..
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Ultrasonographic Features of Papillary Thyroid Carcinoma in Patients with Graves' Disease
Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Korean J Intern Med. 2010;25(1):71-76. Published online February 26, 2010
Background/AimsTo characterize ultrasonographic findings in papillary thyroid carcinoma (PTC) combined with Graves' disease. MethodsMedical records and ultrasonographic findings of 1,013 patients with Graves' disease and 3,380 patients without G..
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Clinical Characteristics of Pulmonary Embolism with Underlying Malignancy
Ji Eun Lee, Hye-Ryoun Kim, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young-Soo Shim, Seok-Chul Yang
Korean J Intern Med. 2010;25(1):66-70. Published online February 26, 2010
Background/AimsThe risk of venous thromboembolism (VTE), which encompasses deep vein thrombosis and pulmonary embolism (PE), increases in patients with cancer. Anticancer treatment is also associated with an increased risk for VTE. We conducted this study to investigate the cl..
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Gastric Yolk Sac Tumor: A Case Report and Review of the Literature
Yeon Soo Kim, Seok Hyun Kim, Jae Koo Seong, Byung Seok Lee, Hyun Yong Jeong, Kyu Sang Song
Korean J Intern Med. 2009;24(2):143-146. Published online June 8, 2009
Gastric yolk sac tumors are extremely rare and their prognosis is poor; most patients have widespread metastases at the time of diagnosis. The treatment of gastric yolk sac tumors consists of aggressive chemotherapy combined with radiotherapy and surgery. Here, we first report a case of gastric y..
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Hepatitis B Reactivation During Adjuvant Anthracycline-Based Chemotherapy in Patients with Breast Cancer: A Single Institution's Experience
Min Kyoung Kim, Jin Hee Ahn, Sung-Bae Kim, Young-Suk Im, Soon Im Lee, Sei-Hyun Ahn, Byung Ho Son, Gyungyub Gong, Hak-Hee Kim, Woo Kun Kim
Korean J Intern Med. 2007;22(4):237-243. Published online December 20, 2007
BackgroundThe objectives of this study were to determine the incidence, outcome and risk factors for HBV reactivation in HBsAg positive breast cancer patients while on anthracycline -based adjuvant chemotherapy. MethodsWe retr..
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Extraskeletal Ewing's Sarcoma of the Head and Neck Presenting as Blindness
Sung In Cho, Yeon Hee Park, Jang Hyun Cho, Baek-Yeol Ryoo, Sung Hyun Yang, Sang Min Youn, Jae Soo Ko
Korean J Intern Med. 2007;22(2):133-137. Published online June 30, 2007
Extraskeletal Ewing's sarcoma is rarely found in the head and neck regions. We report an unusual case of extraskeletal Ewing's Sarcoma of the parapharynx region in a 49-year-old man who presented with blindness. MRI examination showed marked enhancement of tumor thrombosis involving the superior ..
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A Case of a Composite Adrenal Medullary Tumor of Pheochromocytoma and Ganglioneuroma Masquerading as Acute Pancreatitis
Eun-Kyoung Choi, Wan-Ho Kim, Keun-Yong Park
Korean J Intern Med. 2006;21(2):141-145. Published online June 30, 2006
Composite adrenal medullary tumors, composed of both pheochromocytoma and ganglioneuroma, are extremely rare, as are pheochromocytomas masquerading as acute relapsing pancreatitis. We recently experienced a case of a 48-year-old male with both these phenomena. The patient complained of an acute o..
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Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency
Jin Ho Baek, Jong Gwang Kim, Shi Nae Kim, Dong Hwan Kim, Sang Kyun Sohn, Young Jun Hong, Kyu Bo Lee
Korean J Intern Med. 2006;21(1):43-45. Published online March 30, 2006
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A 37-year-old female with gastric cancer underwent a curative operation, ..
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Expression of Cyclooxygenase-2 and Bcl-2 in Human Gastric Adenomas
Jee Hyun Park, Kyung Hee Kang, Se Hwan Kim, Jong Hyup Lee, Chang Min Cho, Young Oh Kweon, Sung Kook Kim, Yong Hwan Choi, Han Ik Bae, Mi Sung Kim
Korean J Intern Med. 2005;20(3):198-204. Published online September 30, 2005
BackgroundCyclooxygenase (COX)-2 is the rate-limiting enzyme in prostaglandin synthesis. An increased expression has been implicated in the development and progression of human gastric cancers and colorectal adenomas and cancers. This study aimed to determine the involvement a..
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The Efficacy of Paclitaxel and Cisplatin Combination Chemotherapy for the Treatment of Metastatic or Recurrent Gastric Cancer: a Multicenter Phase II Study
Sang Joon Shin, Sung Ho Chun, Kyeong Ok Kim, Min Kyoung Kim, Kyung Hee Lee, Myung Soo Hyun, Sung Hwa Bae, Hun Mo Ryoo, Young Rok Do, Ki Young Kwon, Hong Suk Song
Korean J Intern Med. 2005;20(2):135-140. Published online June 30, 2005
BackgroundAlthough many treatments for advanced gastric cancer have been developed, only poor treatment results have generally been obtained. We performed a prospective study on the combination chemotherapy of paclitaxel and cisplatin (PC). The primary objectives of the study ..
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Solitary Intra-abdominal Tuberculous Lymphadenopathy Mimicking Duodenal GIST
You Sun Kim, Jeong Seop Moon, Jung Whan Lee, Il Kim, Soo Hyung Ryu, In Wook Paik
Korean J Intern Med. 2005;20(1):72-75. Published online March 31, 2005
Tuberculosis remains prevalent in developing countries and has recently re-emerged in the Western world. Intra-abdominal tuberculosis can mimic a variety of other abdominal disorders, and here we describe a patient with solitary tuberculous mesenteric lymphadenopathy mimicking duodenal gastrointe..
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